The objective of the present study was to evaluate how accurate the predicted pharmacokinetic (PK) parameters of some drugs are in camels, obtained by allometric scaling from animal species when compared to observed values established by us previously. The PK parameters tested were plasma clearance (Cl) and volume of distribution at steady state (Vss). The drugs evaluated were amikacin, gentamicin, kanamycin, tobramycin, antipyrine, flunixin, ketoprofen (R), ketoprofen (S), meloxicam, phenylbutazone, theophylline, and tramadol. The PK parameters scaled well for all drugs tested except meloxicam, where the predicted Cl was 12.5 fold greater than the observed value.
Key words: Allometry, camels, clearance, volume of distribution
Home